lauramine oxide toxicity
Over two-thirds of the radioactivity expired as 14CO2 appeared within 12 hr after administration of either dose.

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The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.

At least some ingredient disclosure. Login failed. 1-dodecanamine, N,n-dimethyl-, N-oxide (9ci), 105. For more information view the SAGE Journals Sharing page. The international Organisation for Economoic Co-operation and Development reported that amine oxides do not cause dermal sensitization. Rice DP; Toxicol Appl Pharmacol 39 (3): 377 (1977). Up and down procedure for estimating acute oral toxicity (LD50) in rats of GO955.01 [foam formulation containing 0.3% Lauramine Oxide] and GO932.01 [liquid formulation containing 0.3% Lauramine Oxide]. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Study no.

Detergents Ingredients Database - EU Ecolabel. Urinary metabolites in rats, rabbits and humans suggested metabolism via omega, beta-oxidation of the aliphatic chain, amine oxide reduction and aliphatic, mid-chain hydroxylation. 10821. Potentially significant hazards to health or the environment or poor ingredient disclosure.

(. Biodegradability biodegradable.. Characteristics excellent emulsifying, dispersing, foaming, foam stabilizing, antistatic, solubilizing, wetting, permeating abilities.Mild surfactant. At 0.3%, Lauramine Oxide was not a sensitizer in clinical studies. The European Union Ecolabel program reports this substance is readily biodegradable. An oral or cutaneous dose of N,N-dimethyl dodecylamine N-oxide was rapidly absorbed and metabolized by rats. Over 72 hr, 14.2% of the total radioactivity was found in the urine, 2.5% in the CO2, and 1.8% in the feces. 089-0116. NTIS No. Lauramine Oxide at 0.1% in drinking water was not carcinogenic in rats, but at 0.1% with 0.2% sodium nitrate did increase the incidence of liver neoplasms.

Click the button below for the full-text content, 24 hours online access to download content. Prepared for the Army Medical Research and Development by the Committee on Toxicology contract DAMD-17-82-C-3028. *, Estrin NF , Crosley PA , Haynes CR , eds. Aqueous (methyl-14C)lauramine oxide (10 mg containing 1.3 mCi/g) was applied to the skin of four Sprague-Dawley rats to test metabolism and absorption of the compound. Washington, DC. Oral administration of a solution containing 50 mg (1-dodecyl-14C)lauramine oxide (100 uCi of 14C) to two humans resulted in excretion patterns of radioactivity similar to that of the other species studied. 60803842. European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life. EWG is in the process of updating this score.

Journal of the American College of Toxicology, Urinary bladder neoplasms in Syrian hamsters after administration of N-nitroso-N-methyl-N-dodecylamine, Methods for detecting carcinogens and mutagens with the Sa/monella/mammalian-microsome mutagenicity test, The relationship between mutagenicity and carcinogenicity of some nitrosamines, Mutagenicity of amine drugs and their products of nitrosation, Comparison of the carcinogenic effects of five nitrosamines in guinea pigs, Amine nitrosation and nitrosation by gaseous nitrogen dioxide, International Agency for Research on Cancer, Amine oxides. Two groups of four male and one group of four female Sprague-Dawley rats were given 100 mg/kg of (methyl-14C)lauramine oxide (specific activity 1.3 mCi/g) or (1-dodecyl-14C)lauramine oxide (specific activity 1 mCi/g) orally in a metabolic study. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. At 0.3%, Lauramine Oxide was not a sensitizer in clinical studies. Human cumulative irritation. Cutaneous Toxicity, Washington, DC, May 16-18,1976. N,n-dimethyldodecylamine N-oxide Solution, 104. (1989a) Submission of unpublished data by CTFA.

A quote from the Journal of the American College of Toxicity: “Lauramine Oxide produced severe dermal reactions in rabbits, but at 0.3% only slight to moderate erythema with slight edema, fissuring, and slight to moderate epithelial desquamation were found.”


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